1806 — Smallpox, New York City, NY (out of 2,225 deaths from all causes in NYC) — 48

–48  Jones. Contagious and Infectious Diseases. 1884, p. 193.[1]

Source

Jones, Joseph, M.D., President of the Board of Health of the State of Louisiana. Contagious and Infectious Diseases, Measures for Their Prevention and Arrest. Small Pox (Variola); Modified Small Pos (Varioloid); Chicken Pox (Varicella); Cow Pox (Variola Vaccinal): Vaccination, Spurious Vaccination Illustrated by Eight Colored Plates (Circular No. 2, Prepared for the Guidance of the Quarantine Officers and Sanitary Inspectors of the Board of Health of the State of Louisiana.). Baton Rouge: Leon Jastremski, State Printer, 1884. Accessed 2-12-2015 at: https://books.google.com/books?id=3VTboPycbBgC&printsec=frontcover#v=onepage&q&f=false

[1] Table: “Introduction of Vaccination into New York. Total Deaths from all Causes, and from Small-Pox, Measles, Scarlet Fever and Phthisis-Pulmonalis in the City of New York during a Period of Fifty Years, 1804-1853.”